Effect of Different Mydriatic Regimens Used for Pupil Dilation on the Vital Signs of Premature Infants for Retinopathy of Prematurity Screening in a Philippine Tertiary Hospital: A Randomized Double-Blind Clinical Trial

Objectives. To determine the safety and efficacy of three different mydriatic regimens in premature infants referred for retinopathy prematurity (ROP) screening using (1) multiple alternate instillations 0.5% cyclopentolate hydrochloride 2.5% phenylephrine (MAI), (2) single instillation 0.5%/0.5% tropicamide + (SI) (3) with a cotton wick placed inferior fornix (SIW) Philippine tertiary hospital. Methods. A randomized, double-blind, clinical trial included preterm ROP at hospital. After via MAI, SI, SIW, systolic blood pressure (SBP), diastolic (DBP), mean arterial (MAP), heart rate, oxygen saturation were monitored. Pupillary dilation was also measured. Results. Sixty infants, 20 to each intervention, included. The MAI group did not have significant changes relative its baseline vital signs. use SI produced lower DBP (p<0.0106) MAP (p<0.0027) compared MAI. (p<0.01) (p<0.003) SIW exhibited increases SBP (p<0.002) (p<0.04) This increase exceeded normal values <37 weeks old infants. differences among groups (p=0.24). Conclusion. Due SBP, it is recommended discontinue since may promote mydriatic’s systemic absorption. Except clinically increased rate aged ≥37 examination, found be par recommendation UK Guidelines May 2008.